Program

Timetable

General Session

Honor Invited Lecture

November 16 (Tue.) 18:00-19:00 Room A

Development of DNA/RNA heteroduplex oligonucleotide

  • Chair : Takafumi Komori
  • Biopharmaceutical Assessments Core Functional Unit, Medicine Development Center, Eisai Co., Ltd.
  • Speaker : Takanori Yokota
  • Department of Neurology and Neurological Science, Tokyo Medical and Dental University

Distinguished Lecture 1

November 17 (Wed.) 17:10-18:10 Room A

Translation of transporter research into complex clinical pharmacology scenarios – where do endogenous biomarkers fit in?

  • Chair : Ikumi Tamai
  • Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Speaker : Aleksandra Galetin
  • Division of Pharmacy and Optometry, School of Health Sciences, The University of Manchester

Distinguished Lecture 2

November 18 (Thu.) 13:15-14:15 Room A

Role of bile acids, gut bacteria, and intestine transcription factor signaling pathways in metabolic diseases, and pharmacological interventions

  • Chair : Takeo Nakanishi
  • Graduate School of Pharmacy, Takasaki University of Health & Welfare
  • Speaker : Frank J. Gonzalez
  • Center for Cancer Research, National Cancer Institute, National Institutes of Health

President’s Lecture

November 16 (Tue.) 19:00-19:30 Room A

Message from the president

  • Chair : Fumiyoshi Yamashita
  • Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
  • Speaker : Yoshiro Saito
  • Div. Medicinal Safety Science, National Institute of Health Sciences

New President's Lecture

November 18 (Thu.) 15:50-16:10 Room A

Message from the new president

  • Chair : Takuo Ogihara
  • Graduate School of Pharmacy, Takasaki University of Health & Welfare
  • Speaker : Fumiyoshi Yamashita
  • Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University

Chair's Symposium 1

November 17 (Wed.) 9:30-11:45 Room B

Cutting-edge research tools with human tissue-derived materials for the boosting of ADMET research

  • Chair : Takafumi Komori
  • Biopharmaceutical Assessments Core Functional Unit, Medicine Development Center, Eisai Co., Ltd.
  • Chair : Kazuya Maeda
  • Laboratory of Pharmaceutics, Kitasato University School of Pharmacy
  • CSY1-1 "Characters and Evaluations of Primary cell based 3D tissue models by MatTek; focusing on Small Intestinal, Airway and EpiDerm models"
  • Speakers : Yuki Handa
  • Technical Development Department Advanced Technology Division, KURABO Industries Ltd.
  •  Seyoum Ayehunie
  • MatTek Corporation
  • CSY1-2 "Functional applications using gastrointestinal organoids"
  • Speakers : Ryan Conder
  • STEMCELL Technologies Inc.
  •  Kanta Koduka
  • Veritas Corporation
  • CSY1-3-1 "Characteristics of FUJIFILM human iPS cell-derived Small Intestinal Epithelial like Cells (F-hiSIEC™)"
  • Speaker : Shinji Mima
  • Bioscience & Technology Development center, FujiFilm Corporation
  • CSY1-3-2 "Study of intestinal absorption of polyphenols using human iPS cell-derived small intestinal epithelial like cell F-hiSIEC"
  • Speaker : Shunta Shigemura
  • R&D-Safety Science Research, Kao Corporation
  • CSY1-4-1 "Supporting drug research and development with iPSC technologies"
  • Speaker : Makoto Honda
  • Sales & Marketing Department, REPROCELL Inc.
  • CSY1-4-2 "Development of a novel method for differentiation of intestinal cells from human induced pluripotent stem cells"
  • Speaker : Nobuaki Shiraki
  • Tokyo Institute of Technology, School of Life Science and Technology

Chair's Symposium 2

November 19 (Fri.) 9:30-11:45 Room C

Educational Symposium "Message to Young Drug Metabolism and Pharmacokinetic Researchers"

  • Chair : Koujirou Yamamoto
  • Gunma University Graduate School of Medicine
  • Chair : Kentaro Yano
  • Laboratory of Drug Metabolism and Pharmacokinetics, Yokohama University of Pharmacy
  • CSY2-1 "The mission and determination of researchers at pharmaceutical companies"
  • Speaker : Masayuki Takahashi
  • Pharmaceutical & ADMET Research Department, Daiichi Sankyo RD Novare Co., Ltd.
  • CSY2-2 "Go on to the doctoral course at graduate school and become a university professor- analysis of the present state and prospects of the future -"
  • Speaker : Masahiro Hayashi
  • Takasaki University of Health and Welfare/ Tokyo University of Pharmacy and Life Sciences
  • CSY2-3 "Ingenuity for writing articles with high-impact"
  • Speaker : Tetsuya Kamataki
  • Hokkaido University/ Takasaki University of Health and Welfare
  • CSY2-4 "Tips for Paper Writing and Reviewing"
  • Speaker : Sumio Ohtsuki
  • Faculty of Life Sciences, Kumamoto University

Symposium 1(New Modality DIS)

November 17 (Wed.) 9:30-11:45 Room A

Advanced DMPK researches for breaking new ground in cell-based products

  • Organizer : Takashi Kuwabara
  • Laboratory of Biologics evaluation, Yokohama University of Pharmacy
  • Chair : Yoichi Naritomi
  • Healios K.K.
  • Chair : Syunsuke Yamamoto
  • Drug Metabolism & Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited
  • SY1-1 "MEASURE: Trend Analyses and Multisite-Studies of Biodistribution Evaluation for Cell Therapy Products"
  • Speaker : Yoshiteru Kamiyama
  • Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
  • SY1-2 "Contribution of DMPK researcher on cell therapy program : Establishment of cell quantification platform for the quantitative cellular kinetic analysis"
  • Speaker : Syunsuke Yamamoto
  • Drug Metabolism & Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited
  • SY1-3 "In vivo fluorescence imaging of transplanted stem cells by nano-quantum sensors for regenerative medicine"
  • Speaker : Hiroshi Yukawa
  • Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University
  • SY1-4 "Cellular kinetics of tisagenlecleucel for anti-CD19 chimeric antigen receptor (CAR)-T cell therapy"
  • Speaker : Takeshi Tajima
  • PK Sciences, Translational Medicine, Novartis Pharma K.K.
  • SY1-5 "Preclinical, Translational and Clinical Quantitative Systems Pharmacology Modeling Approaches for Cell Therapies"
  • Speaker : Aman P Singh
  • Cell Therapy Clinical Pharmacology, Cell Product Clinical Translation, Takeda, Cambridge MA

Symposium 2 (Drug Metabolism and Drug Induced Toxicity DIS)

November 17 (Wed.) 9:30-11:45 Room C

Impact of extrahepatic metabolism on efficacy and toxicity of drugs

  • Organizer : Miki Nakajima
  • Faculty of Pharmacueitcal Sciences, Kanazawa University/WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
  • Chair : Tetsuya Nakagawa
  • Sumitomo Dainippon Pharma Co., Ltd.
  • Chair : Kaoru Kobayashi
  • Meiji Pharmaceutical University
  • SY2-1 "Expression profile and drug response of cytochrome P450s in human neuronal and glial cell lines"
  • Speaker : Satoshi Yamaori
  • Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • SY2-2 "Physiological Functions of Cytochrome P450 and Aldehyde Oxidase in Extrahepatic Tissues"
  • Speaker : Seigo Sanoh
  • School of Pharmaceutical Sciences, Wakayama Medical University
  • SY2-3 "Application of human iPS cell-derived intestinal cells for evaluation of drug disposition"
  • Speaker : Takahiro Iwao
  • Graduate School of Pharmaceutical Sciences, Nagoya City University
  • SY2-4 "Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine"
  • Speaker : Takanori Akazawa
  • Laboratory for Advanced Medicine Research, SHIONOGI & CO., LTD.
  • SY2-5 "Evaluation of intestinal metabolism in humanized animals"
  • Speaker : Kaoru Kobayashi
  • Meiji Pharmaceutical University

Symposium 3 (BioAnalysis and BioImaging DIS)

November 17 (Wed.) 14:30-17:00 Room B

Collaborative Symposium of Users and Equipment Makers on Imaging Mass Spectrometry: Application to Drug Discovery and Development and Regulations.

  • Chair : Kosuke Saito
  • National Institute of Health Sciences
  • Organizer/Chair : Junji Komaba
  • Ono Pharmaceutical Co., Ltd.
  • SY3-1 "Distribution studies of phytochemicals in animal tissues using imaging mass spectrometry"
  • Speaker : Takashi Matsumoto
  • Tsumura & Co.
  • SY3-2 "Application of Imaging Mass Spectrometry to Peptide Drug Discovery"
  • Speaker : Yukari Tanaka
  • Drug Metabolism and Pharmacokinetics 2 Group, Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd.
  • SY3-3 " International Survey on Imaging Mass Spectrometry Methods and Applications for Drug Discovery and Development"
  • Speaker : Yukari Tanaka
  • Japan Association for Imaging Mass Spectrometry
  • SY3-4 "Biomedical Application of Imaging Mass Spectrometry in pharmaceutical research"
  • Speaker : Kenichi Watanabe
  • Sumitomo Dainippon Pharma Co., Ltd.
  • SY3-5 "Introduction of Drug Discovery Utilization of Atmospheric Pressure MALDI IMS System Composed of Q-Exactive and AP-SMALDI 10"
  • Speaker : Kouji Tanaka
  • Mitsubishi Tanabe Pharma Corporation Sohyaku. Innovative Research Division DMPK Research Laboratories
  • SY3-6 "The latest information of iMScope QT system"
  • Speaker : Ryo Yamaguchi
  • Analytical and Measuring Instruments Division, Shimadzu Corporation
  • SY3-7 "Molecular imaging by extreme resolution mass spectrometry"
  • Speaker : Takashi Nirasawa
  • Bruker Japan K.K.
  • SY3-8 "Utilization of DESI imaging in pharmacokinetic studies"
  • Speaker : Motoji Oshikata
  • Nihon Waters K.K.
  • SY3-9 "Introduction of atmospheric-pressure scanning microprobe matrix-assisted laser desorption/ionization (AP-SMALDI) on Q Exactive Hhybrid quadrupole-Orbitrap mass spectrometer"
  • Speaker : Kentaro Takahara
  • Thermo Fisher Scientific
  • SY3-10 "ICP-MS equipment description and introduction of bioimaging by laser ablation ICP-MS(LA-ICP-MS)"
  • Speaker : Mineko Omori
  • Agilent Technologies Japan, Ltd.

Symposium 4 (Drug Absorption DIS)

November 17 (Wed.) 14:30-17:00 Room C

DRUG ABSORPTION FROM SCRATCH: Food Effects on Oral Drug Absorption and Pharmacokinetics -Based on Collaboration between Researchers Involved with Pharmacokinetics, Formulation and Clinical Development-

  • Organizer/Chair : Yoshiyuki Shirasaka
  • Faculty of Pharmacy, Kanazawa University
  • Chair : Yoshiyuki Yamaura
  • Pharmacokinetic Research Labs., Ono Pharmaceutical Co., Ltd.
  • SY4-1 "Pharmacokinetic Perspective: Quantitative analysis of the effect of gastrointestinal physiology on food/beverage-drug interactions"
  • Speaker : Yoshiyuki Shirasaka
  • Faculty of Pharmacy, Kanazawa University
  • SY4-2 "Physicochemical perspective: Assessment of the food effects on oral drug absorption during the preclinical stage"
  • Speaker : Koichi Nakamura
  • Drug Metabolism and Pharmacokinetics Research Labs., Daiichi Sankyo Co., Ltd.
  • SY4-3 "Formulation Perspective: Prediction of food effect on in vivo performance of oral dosage forms – from the basics to the latest research outcomes"
  • Speaker : Atsushi Kambayashi
  • Pharmaceutical Research and Technology Labs., Astellas Pharma Inc.
  • SY4-4 "Clinical Development Perspective: Impact of food-effect bioavailability on clinical development for new drug"
  • Speaker : Mari Shiomi
  • MSD K.K. Japan Development

Symposium 5 (Modeling & Systems Pharmacology DIS)

November 18 (Thu.) 9:15-11:45 Room A

Latest Advances in Modell Informed Drug Discovery and Development (MID3) for Oncology Research

  • Organizer : Yasuhisa Nagasaka
  • Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
  • Chair : Takayo Ueno
  • Bristol Myers Squibb
  • Chair : Teruki Hamada
  • Axcelead Drug Discovery Partners, Inc.
  • SY5-1 "Application of a quantitative systems pharmacology model in model-informed drug discovery and development –A case example of a novel KRASG12C inhibitor–"
  • Speaker : Hiroyuki Sayama
  • Quantitative Systems Pharmacology, Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
  • Chair : Ryosei Leo Kawai
  • Chuo Translational Science, LLC
  • Chair : Tsuyoshi Minematsu
  • Quantitative Systems Pharmacology, Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
  • SY5-2 "A Quantitative Systems Pharmacology platform for the analysis of syngeneic murine tumor dynamics data: Re-thinking clinical translation in Immuno-Oncology"
  • Speaker : Gabriel Helmlinger
  • Obsidian Therapeutics, Cambridge MA, USA
  • Chair : Hiroto Hatakeyama
  • Graduate School of Pharmaceutical Sciences, Chiba University
  • Chair : Ryoko Sawamura
  • Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd.
  • SY5-3 "QSP model development, utilization and repurposing for immuno-oncology therapies"
  • Speaker : Oleg Milberg
  • Moderna, Inc.
  • Chair : Shinichi Kijima
  • Office of Advanced Evaluation with Electronic Data, Pharmaceuticals and Medical Devices Agency
  • Chair : Masayo Oishi
  • Quantitative Systems Pharmacology, Analysis and Pharmacokinetics Research Labs., Astellas Pharma Inc.
  • SY5-4 "Case Example: Application of Model-Informed Drug Development in Oncology Product"
  • Speaker : Mayu Osawa
  • Bristol-Myers Squibb K.K. Japan R&D Clinical Pharmacology Strategy
  • Panel discussion
  • Moderator : Koji Chiba
  • Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
  • Moderator : Yasuhisa Nagasaka
  • Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
  • Panelist : Chihiro Hasegawa
  • MSD (Merck Sharp & Dohme) Clinical Pharmacology Development, Clinical Research Area, Japan Development

Symposium 6(Microphysiological system and iPS DIS)

November 18 (Thu.) 9:30-11:45 Room B

The future of MPS and iPSC-derived cell applications for drug evaluation

  • Chair : Seiichi Ishida
  • Division of Applied Life Science, Graduate School of Engineering, Sojo University
  • Chair : Hideki Hirabayashi
  • Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited
  • SY6-1 "Current status of MPS and iPSC-derived cell applications for drug evaluation"
  • Speaker : Seiichi Ishida
  • Division of Applied Life Science, Graduate School of Engineering, Sojo University
  • SY6-2 "Prospects for development of drug evaluation systems utilizing iPSC-derived cells and MPS"
  • Speaker : Tamihide Matsunaga
  • Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • SY6-3 "Expectations for MPS and iPSC-derived cells to drug discovery and development from the standpoint of pharmaceutical company"
  • Speaker : Kazutomi Kusano
  • Global Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd.
  • SY6-4 "Utilization of Microphysiological Systems in Drug Metabolism and Pharmacokinetics to Understand Drug Disposition"
  • Speaker : Donald L McKenzie
  • LabCorp Laboratories Inc.

Symposium 7 (Drug Metabolism and Drug Induced Toxicity DIS)

November 18 (Thu.) 9:30-11:45 Room C

Recent advances in the understanding of functions, regulations and species differences of drug-metabolizing enzymes

  • Organizer : Miki Nakajima
  • Faculty of Pharmacueitcal Sciences, Kanazawa University/WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
  • Chair : Seigo Sanou
  • School of Pharmaceutical Sciences, Wakayama Medical University
  • Chair : Kouichi Yoshinari
  • School of Pharmaceutical Sciences, University of Shizuoka
  • SY7-1 "Structural Biology of Enzymes Involved in Natural Product Biosynthesis"
  • Speaker : Shingo Nagano
  • Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University
  • SY7-2 "Species differences in drug metabolism and toxicity"
  • Speaker : Mayumi Ishizuka
  • Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University
  • SY7-3 "Epitranscriptional regulation of drug-metabolizing enzymes"
  • Speaker : Miki Nakajima
  • Faculty of Pharmacueitcal Sciences, Kanazawa University/WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
  • SY7-4 "Gene regulation by nuclear receptors: drug metabolism and liver toxicity"
  • Speaker : Kouichi Yoshinari
  • School of Pharmaceutical Sciences, University of Shizuoka

Symposium 8 (DDS DIS)

November 18 (Thu.) 9:30-11:45 Room D

DDS technology in nucleic acid and gene drug development

  • Chair : Shigeru Kawakami
  • Graduate School of Biomedical Sciences, Nagasaki University
  • Organizer/Chair : Tastuhiro Ishida
  • Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University
  • SY8-1 "Accelerated Blood Clearance Phenomenon in the Development of LNP Formulation"
  • Speaker : Kenji Hyodo
  • hhc Data Creation Center, Eisai Co., Ltd.
  • SY8-2 "Polymer design for controlling the biodistribution of oligonucleotide drugs"
  • Speaker : Kanjiro Miyata
  • Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
  • SY8-3 "Structural optimization of oligonucleotide therapeutics for controlling in vivo distribution"
  • Speaker : Makiya Nishikawa
  • Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • SY8-4 "Development of a theranostics system for ultrasound-responsive nucleic acid and gene delivery"
  • Speaker : Yoichi Negishi
  • Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • SY8-5 "Pharmacokinetic evaluation methods for the nanoparticle formulations of nucleic acid and mRNA-based therapeutics"
  • Speaker : Hidefumi Mukai
  • Graduate School of Biomedical Sciences, Nagasaki University/RIKEN Center for Biosystems Dynamics Research, Laboratory for Molecular Delivery and Imaging Technology

Symposium 9 (Regulation DIS)

November 19 (Fri.) 9:30-11:45 Room A

Latest trends of regulation on pharmacokinetics: new modality, drug interactions (ICHM12) and nonclinical biodistribution for gene therapy products(ICHS12)

  • Organizer : Naomi Nagai
  • Musashino University
  • Chair : Kosuke Saito
  • National Institute of Health Sciences
  • Chair : Takafumi Iwatsubo
  • Astellas Pharma Inc.
  • SY9-1 "Evaluation of drug-drug interaction in antibody-drug conjugate"
  • Speaker : Akiko Watanabe
  • Quantitative Clinical Pharmacology Department, DAIICHI SANKYO CO., LTD.
  • SY9-2 "Perspectives towards ICH M12: Drug Interaction Studies"
  • Speaker : Akihiro Ishiguro
  • Pharmaceuticals and Medical Devices Agency
  • SY9-3 "Current development status and DMPK properties of oligonucleotide therapeutics"
  • Speaker : Takao Inoue
  • National Institute of Health Sciences
  • SY9-4 "Mass spectrometry-based bioanalysis for oligonucleotide therapeutics"
  • Speaker : Yuchen Sun
  • National Institute of Health Sciences
  • SY9-5 "ICH S12 Step2 document on "Nonclinical Biodistribution Considerations for Gene Therapy Products"
  • Speaker : Mizuho Nonaka
  • Pharmaceuticals and Medical Devices Agency

Symposium 10 (Drug Efficacy and Safety DIS)

November 19 (Fri.) 9:30-11:45 Room B

Prediction strategies for efficacy and safety of cancer immunotherapy

  • Organizer/Chair : Satoru Koyanagi
  • Faculty of Pharmaceutical Sciences, Kyushu University
  • Chair : Hiroshi Watanabe
  • School of Pharmacy, Kumamoto University
  • SY10-1 "Clinical Pharmacology (Pharmacokinetics and Pharmacodynamics) of Immune Check-point Inhibitor"
  • Speaker : Yoshinori Makino
  • Department of Cancer Genome Medicine/Department of Pharmacy, Saitama Medical University International Medical Center
  • SY10-2 "Evaluation of pharmacokinetics and efficacy of Immune checkpoint inhibitors- lessons from mouse tumor models"
  • Speaker : Hiroto Hatakeyama
  • The laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
  • SY10-3 "Exploration of predictive biomarker for immune checkpoint inhibitor"
  • Speaker : Naoki Inui
  • Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine
  • SY10-4 "The development of measuring method for occupancy of anti-PD-1 monoclonal antibody on the target cells: implication for cancer immunotherapy"
  • Speaker : Koichiro Matsumoto
  • Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
  • SY10-5 "Current status and future perspectives of CAR-T therapy"
  • Speaker : Ryosuke Uchibori
  • Division of Immuno- Gene & Cell Therapy (Takara Bio), Jichi Medical University

Symposium 11 (Drug Metabolism and Drug Induced Toxicity DIS)

November 19 (Fri.) 13:15-15:45 Room A

Pharmacokinetics / Safety Research for Medium-Molecule Drug Discovery : From Basic Research to Regulatory Science

  • Organizer : Miki Nakajima
  • Faculty of Pharmacueitcal Sciences, Kanazawa University/WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
  • Chair : Kousei Ito
  • Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Chair : Yoshiteru Kamiyama
  • Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
  • SY11-1 "Experimental approach to evaluating the oral bioavailability of peptides, with a focus on membrane permeability, P-glycoprotein mediated efflux and cytochrome P450 metabolism"
  • Speaker : Daigo Asano
  • Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
  • SY11-2 "Developments of nucleic acid-based drugs from the point of view of academia"
  • Speaker : Fumito Wada
  • Liid Pharmaceuticals, Inc.
  • SY11-3 "Pharmacokinetics and safety assessment of the therapeutic oligonucleotide viltolarsen"
  • Speaker : Yusuke Suda
  • Pharmacokinetics and Safety Assessment Department, Drug Discovery Laboratories, Research and Development Division, Nippon Shinyaku Co., Ltd.
  • SY11-4 "Preclinical safety assessment of mRNA targeting oligonucleotide therapeutics"
  • Speaker : Mizuho Suzuki
  • Office of New Drug Ⅲ, Pharmaceuticals and Medical Devices Agency (PMDA)

Symposium 12 (Transporter DIS)

November 19 (Fri.) 13:15-15:45 Room B

Strategies and technologies for drug discovery targeting transporters

  • Organizer/Chair : Katsuhisa Inoue
  • School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • Chair : Kazuya Maeda
  • Laboratory of Pharmaceutics, Kitasato University School of Pharmacy
  • SY12-1 "Development of Innovative Treatment of Central Nervous System Diseases with Nanomachines"
  • Speaker : Yasutaka Anraku
  • Graduate School of Engineering, The University of Tokyo
  • SY12-2 "Cancer treatment strategy targeting amino acid transporter LAT1"
  • Speaker : Yoshikatsu Kanai
  • Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University
  • SY12-3 "Functional evaluation of drug transporters in 2D- and 3D-cultured human iPS cell-derived blood–brain barrier models"
  • Speaker : Toshiki Kurosawa
  • Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma Sciences, Teikyo University
  • SY12-4 "SLC13A5 as a potential therapeutic target for metabolic disease and cancer"
  • Speaker : Kei Higuchi
  • Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Symposium 13 (Educational and Crosscutting DIS)

November 19 (Fri.) 13:15-15:45 Room C

Basic course of pharmacokinetics on cross-disciplinary

  • Organizer/Chair : Tamihide Matsunaga
  • Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • Chair : Seigo Sanou
  • School of Pharmaceutical Sciences, Wakayama Medical University
  • SY13-1 "ILSI Japan's Approach to Predicting Internal Exposure Doses for Food Safety and Functionality Assessment"
  • Speaker : Satoshi Ota
  • International Life Sciences Institute Japan (ILSI Japan)
  • SY13-2 "Introduction of technologies used to evaluate the safety of cosmetic ingredients"
  • Speaker : Shuichi Sekine
  • Global Innovation Center, Shiseido Co., Ltd.
  • SY13-3 "Basic and up-to-date knowledge of drug-metabolizing enzymes to promote understanding of pharmacokinetics and toxicity"
  • Speaker : Tatsuki Fukami
  • Faculty of Pharmaceutical Sciences, Kanazawa University
  • SY13-4 "Importance of understanding the effects of the unbound fraction on pharmacokinetics"
  • Speaker : Takahiro Shibayama
  • Drug Metabolism and Pharmacokinetics Research Laboratories, DAIICHI SANKYO CO., LTD.

Asia Joint Symposium

November 17 (Wed.) 14:30-17:00 Room A

New challenges for infectious diseases in Asia

  • Chair : Masatoshi Tomi
  • Faculty of Pharmacy, Keio University
  • JSY-1 "International comparison of the spread of Coronavirus infection"
  • Speaker(JSSX) : Akihiro Hisaka
  • Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
  • JSY-2 "Identification of brevinin-1EMa-derived stapled peptides as broad-spectrum virus entry blockers"
  • Speaker(KSAP) : Choongho Lee
  • College of Pharmacy, Dongguk University, Goyang, Republic of Korea/Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Republic of Korea
  • JSY-3 "Pharmacogenomics: A new perspective on personalized medicine for Infectious diseases"
  • Speaker(PTST) : Chonlaphat Sukasem
  • Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand/Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, 10400, Thailand
  • JSY-4 "Using Physiologically-based PK/PD modeling and simulation to inform design of intramuscular antiviral drugs"
  • Speaker(CSSX) : Emile P. Chen
  • System Modeling and Translational Biology, GlaxoSmithKline

The Predoctoral Researcher-Initiative Session(PRIS) 2021

November 18 (Thu.) 14:15-16:15 Room B

Unstoppable Challenge by Next Generation Researchers in Post-corona virus Period

  • Organizer : Ryuto Tomabechi
  • Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences
  • Organizer : Yugo Ikeyama
  • Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Chair : Ryuto Tomabechi
  • Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences
  • PSY-1(Education Lecture) "Challenge to clarify the role of endoplasmic reticulum membrane transporters in drug metabolism"
  • Speaker : Hiroshi Arakawa
  • Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Chair : Yuta Funai
  • Membrane Transport and Biopharmceutics, Faculty of Pharmaceutical Sciences, Kanazawa University
  • PSY-2 "Investigation for the development of an in vitro system with differentiated cells derived from three-dimensional human intestinal spheroids to evaluate drug intestinal absorption"
  • Speaker : Kazuyoshi Michiba
  • Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Chair : Kiamu Kurosawa
  • Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University
  • PSY-3 "Effects of m6A modification on hepatic drug and lipid metabolism properties by regulation of carboxylesterase 2"
  • Speaker : Seiya Takemoto
  • Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University
  • Chair : Yusuke Shinozaki
  • Laboratory of Biopharmacuetics, School of Pharmacy and Pharmaceutical Sciences, University of Toyama
  • PSY-4 "Central nervous system (CNS) barrier-targeting drug discovery as a new strategy for CNS disorder treatment: An example of multiple sclerosis"
  • Speaker : Kenta Tezuka
  • Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Chair : Miyuki Takemura
  • Membrane Transport and Biopharmceutics, Faculty of Pharmaceutical Sciences, Kanazawa University
  • PSY-5 "RNA editing enzyme ADAR1 controls renal expression of MRP4 through regulating the production of "circular RNA""
  • Speaker : Yuji Omata
  • Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University
  • Chair : Yugo Ikeyama
  • Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • PSY-6 "Investigation of effects of structurally similar compounds with decomposition profile data analysis toward hit-to-lead optimization"
  • Speaker : Katsuhisa Morita
  • Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Sponsored Seminar 1

November 17 (Wed.) 12:00-13:00 Room A

  • Chair:Shinsuke Aoyama
  • Drug Development Solutions Sales Office, SEKISUI MEDICAL CO., LTD.

High Sensitive Bioanalysis method (PALSAR) for Oligonucleotide Therapeutics

  • Speaker : Takeshi Okuzono
  • Contract Research Department, Drug Development Solutions Center, SEKISUI MEDICAL CO., LTD.

Bioanalytical platforms that support TS-PK/PD research in the era of new modalities

  • Speaker : Fumio Osaki
  • Biomarker, Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.

Sponsored Seminar 2

November 18 (Thu.) 12:00-13:00 Room A

In-depth spatialOMx analysis by imaging mass spectrometry

  • Chair : Shigeru Sakamoto
  • Bruker Japan K.K.
  • Speaker : Takashi Nirasawa
  • Bruker Japan K.K.

Sponsored Seminar 3

November 18 (Thu.) 12:00-13:00 Room B

  • Chair : Takatoshi Nakamura
  • Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.

Introduction to nucleic acid drug analysis by ligand binding assay and liquid chromatography-mass spectrometry assay

  • Speaker : Yosuke Kotani
  • Research Unit 2, Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.

Phenotyping of cytochrome P450 3A enzymes in individual cynomolgus monkeys by endogenous compounds in plasma determined by liquid chromatography-mass spectrometry

  • Speaker : Yasuharu Nakanishi
  • Research Unit 2, Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.

Sponsored Seminar 4

November 18 (Thu.) 12:00-13:00 Room C

Multi-modal tissue imaging with laser ablation-inductively coupled plasma-mass spectrometry for human brains with Alzheimer's disease

  • Chair : Yasuo Kuroki
  • Thermo Fisher Scientific K.K.
  • Speaker : Masaya Ikegawa
  • Department of Life and Medical Sciences, Doshisha University